Notes: This is a good seed if you like multiple tears in one shot. ![]() Notes: Brimstone is on the 4th floor and the Brimstone is on the 4th floor’s Devil Room. ![]() Items: Mutant Spider, Proptosis, Brimstone. Notes: Very OP run that will leave you with triple Brimstone and homing shots to boot. Items: Inner Eye, Almond Milk, Brimstone, Pentagram, Brain Worm. It’s the run that keeps on giving and continues to get stronger the farther you get. Notes: Very fun Isaac seed that leads to some interesting synergies, particularly if playing as Azazel. Items: Rocket in a Jar, Goat Head, Dead Cat, Soy Milk, Blood Clot. Find the secret rooms to make the most of the run (the Bible is in a secret room on Depths II). Items: Ankh, Bible, Tech X, Mutant Spider, Guppy’s Collar, Sausage, Faded Polaroid, Flat File. ![]() As of time of writing, Repentance is only available for the PC, so all the Repentance seeds below are only for PC. ![]() The Best Binding of Isaac Repentance Seeds Best Repentance SeedsĪs the most recent DLC, it was harder to find a lot of the best Binding of Isaac seeds for Repentance, but there are still plenty to be getting on with.
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